SHANGHAI, May 21, 2015 -- A consortium (the “Consortium”) consisting of entities affiliated with Shanghai Fosun Pharmaceutical Group, HOPU Investments, China Everbright Limited’s healthcare fund (“CEL Healthcare Fund”), and WuXi PharmaTech announced today that the Consortium has signed a merger agreement pursuant to which the Consortium will acquire Ambrx Inc. The transaction is expected to close in the second quarter of 2015, subject to receipt of certain regulatory approvals and satisfaction of customary closing conditions. Other details of the transaction were not disclosed.
Ambrx is a clinical-stage biotechnology company focused on discovering and developing first-in-class and best-in-class optimized protein therapeutics known as bio-conjugates. The company’s proprietary technology platforms enable attachment of pharmaceutically active molecules to specific sites within proteins more precisely than prior generations of bio-conjugates and with precision similar to that used to design small-molecule drugs. Ambrx has developed a pipeline of novel product candidates that include antibody-drug conjugates, or ADCs, bi- and multi-specific drug conjugates, and long-acting therapeutic proteins.
ADCs are expected to be one of the most important areas of monoclonal antibody development in the next decade, especially in targeted therapies for oncology, an area where Ambrx has a strong internal pipeline. The company’s most advanced internally developed product is ARX788, a site-specific ADC targeting Her2-positive breast cancer that Ambrx expects to begin clinical trials on in 2015.
In addition to its internal pipeline, Ambrx collaborates with leading pharmaceutical companies, including Bristol-Myers Squibb, Merck, Eli Lilly, and Agensys. Ambrx’s most advanced collaboration product candidate in human health is ARX618, a long-acting fibroblast growth factor 21 for type 2 diabetes, for which collaboration partner Bristol-Myers Squibb is conducting Phase 2 clinical trials in the United States. To date, collaborations have provided Ambrx with over $200 million in funding and have the potential to provide milestone payments and royalties on the sale of collaboration products.
“This transaction brings together the resources of leading China-based life science companies and investors and a leading U.S.-based innovator in biologics development,” said Qiyu Chen, Chairman of Fosun Pharma. “It will also expand Fosun’s existing monoclonal antibody platform. Under the new ownership, Ambrx will have additional resources to advance the development of its innovative technology in its U.S.-based research center and to build a China-based global product development center. Ambrx’s expansion in China will help Chinese patients get faster access to advanced medicines.”
“We are pleased to join the Consortium to acquire Ambrx, a top-tier innovative biologics company with a cutting-edge second-generation ADC technology platform,” said Dr. Ge Li, Chairman and CEO of WuXi PharmaTech. “This transaction will allow WuXi to broadly access Ambrx’s best-in-class ADC platform and biologics development capabilities to better serve our global customers.”
"We are excited to advance Ambrx's development programs and technologies with members of the Consortium," said Ambrx's CEO and President Lawson Macartney, Ph.D., FRCPath. "I would like to thank Ambrx's employees and partners for their dedicated efforts to bring important new therapies to patients."
BMO Capital Markets Corp. is acting as exclusive financial advisor and Latham & Watkins is acting as legal advisor to Ambrx in connection with this transaction. Haynes and Boone is acting as legal advisor to the Consortium in connection with this transaction.
About WuXi PharmaTech
WuXi PharmaTech (NYSE: WX) is a leading open-access R&D capability and technology platform company serving the pharmaceutical, biotechnology, and medical device industries, with operations in China and the United States. As a research-driven and customer-focused company, WuXi PharmaTech provides pharmaceutical, biotechnology, and medical device companies with a broad and integrated portfolio of laboratory and manufacturing services throughout the drug and medical device R&D process. WuXi is also building a platform to provide clinical diagnostic services directly to physicians and their patients globally. WuXi PharmaTech’s services are designed to help its global partners in shortening the cycle and lowering the cost of drug and medical device R&D. The operating subsidiaries of WuXi PharmaTech are known as WuXi AppTec. For more information, please visit: http://www.wuxiapptec.com.
About Shanghai Fosun Pharmaceutical (Group) Co., Ltd.
Shanghai Fosun Pharmaceutical (Group) Co., Ltd. (“Fosun Pharma”), a leading healthcare company in China, was established in 1994 and has been listed on the Shanghai Stock Exchange since August 1998 and on the Main Board of the Hong Kong Stock Exchange since 2012 (stock codes: 600196-SH, 02196-HK). Fosun Pharma strategically covers important segments of the healthcare industry value chain, including pharmaceutical manufacturing, pharmaceutical distribution and retail, healthcare services, diagnostic products, and medical devices. The company maintains a National Recognized Enterprise Technology Centre and a highly capable international R&D team, focusing on innovation and research in therapeutic areas including metabolism and the alimentary tract, the cardiovascular system, the central nervous system, oncology and immunoregulation, and infection. With its commitment to innovation for good health and creating a better future, Fosun Pharma will continue to pursue its strategic development approach of “Organic Growth, Coupled with M&A and Integration.” The Company strives to be one of the first-class enterprises in the global healthcare market. Click here for more information: http://www.fosunpharma.com.
About HOPU Investments
HOPU Investments is a private equity firm focusing on China-related investment opportunities. With offices located in Beijing, Hong Kong, and Singapore, HOPU's team has unique expertise in investment, financing, and capital markets, as well as diverse experience working with state-owned enterprises and private entrepreneurs. HOPU's key investment focus is to create, develop, and pursue investment opportunities driven by China's ongoing economic reforms and development, particularly in the healthcare, technology, consumer, energy, mining, agriculture, and financial services sectors.
About China Everbright Limited’s healthcare fund (“CEL Healthcare Fund”)
China Everbright Limited (CEL) (stock code: 165-HK), a member of China Everbright Group, is a publicly listed diversified financial services enterprise focusing on the asset management and investment businesses. It manages a series of private equity funds, venture capital funds, sector-focused funds, and hedge funds and provides across-the-board investment management services for overseas investors to invest in companies with fast-growing potential in mainland China. CEL also seeks investment opportunities overseas and provides diversified financial services for its clients in mainland China. Total assets under management totaled $6.8 billion as of December 31, 2014. CEL Healthcare Fund focuses on leading healthcare/life science companies with a defendable competitive position, excellent prospects for an expandable platform, and a good fit with the considerable resources and market potential that China has to offer. The CEL team has extensive experience and a network of contacts in the healthcare sectors in China and the United States.
For more information, please contact:
Ronald Aldridge (for investors)
Director of Investor Relations
Aaron Shi (for the media)
Director of Corporate Communications
Shanghai Fosun Pharmaceutical Company
Senior Public Relations Manager
Head of Technology Investments
China Everbright Limited
Head, Managing Director, Healthcare Investment
Senior Account Executive
Russo Partners LLC